Like all women in menopause, women in premature menopause experience lowered estrogen levels as the ovaries stop most of their production of this hormone. Low levels of estrogen can lead to changes in a woman's overall health and may increase her risk for certain medical conditions, such as osteoporosis. Other health risks associated with the loss of estrogen include increase risk for colon and ovarian cancer, periodontal gum disease and tooth loss and cataract formation.

However, compared with women who go through natural menopause, women undergoing premature menopause spend a greater portion of their lives without the protective benefits of their own estrogen. This puts them at an even greater risk for menopause-related health problems.